President Donald Trump’s sweeping executive order aimed at significantly reducing the cost of prescription drugs in the United States targets commercial prices and those for Medicare and Medicaid. The goal is to align U.S. prices with those paid by consumers in other countries.

“Some prescription drug and pharmaceutical prices will be reduced almost immediately by 50 to 80 to 90%,” Trump said. “Big pharma will either abide by this principle voluntarily, or we’ll use the power of the federal government to ensure that we are paying the same price as other countries.”

Progressive Sen. Bernie Sanders, I-Vermont, has waged war with the pharmaceutical industry over drug pricing. He released a statement agreeing with the Trump that prices are too high, but also doubting the executive order will lead to real change.

“As Trump well knows, his executive order will be thrown out by the courts. If Trump is serious about making real change rather than just issuing a press release, he will support legislation I will soon be introducing to make sure we pay no more for prescription drugs than people in other major countries,” the statement from Sanders read in part. “If Republicans and Democrats come together on this legislation, we can get it passed in a few weeks.”

Rep. Ro Khanna, D-Calif., said he would support signing Trump’s order into law.

“I support @realDonaldTrump effort to ensure Americans do not pay more for drugs than those in other countries,” he wrote. “But instead of an EO that will get challenged again by Big Pharma, why not work with @BernieSanders & me to make this law!”

American drug prices are notoriously higher than those in other countries. For example, Humira, used for conditions like rheumatoid arthritis, can cost more than $4,000 a month without insurance in the U.S., compared to around $600 in parts of Europe. Blood thinner Xarelto costs more than $600 a month domestically, while it is about $70 in Canada. Weight loss drug Wegovy, which previously cost as much as $1,200 a month in the U.S., is now priced at $499, compared to around $100 in the UK.

Health and Human Services Secretary Robert F. Kennedy Jr. highlighted the influence of pharmaceutical lobbying.

“Pharmaceutical companies, the industry itself, spend three times what the next largest lobbyist spends on lobbying. So this was an issue that people talked about, but nobody wanted to do anything because it was radioactive, they knew you couldn’t get it by Congress,” he said before the order was signed.

The White House has set a one-month deadline for drug manufacturers to negotiate lower prices. If they fail to do so, the administration plans to implement “most-favored nation” pricing through the Department of Health and Human Services, which would set U.S. prices to match those in other developed countries.

“Over the next 30 days, the four of us up here, together with the people in the back of this room who are doing a lot of the heavy lifting, are going to be approaching pharmaceutical companies to talk specifically about what we want the most favored nation price to be,” said Dr. Mehmet Oz, administrator of the Centers for Medicare & Medicaid Services.

The White House said drugmakers have justified high American prices by citing research and development costs in the U.S., with the president asserting that other countries should share in those expenses. The order has gotten some bipartisan support, but it’s also been met with skepticism.

Senate Majority Leader John Thune, R-S.D., told reporters on Monday, according to the Associated Press, it would be “fairly controversial” if Trump had tried to push through the policy legislatively, rather than through an executive order.

But Sanders, in his statement, said something needs to be done about exploding drug prices.

“It is an outrage that the American people pay, by far, the highest prices in the world for prescription drugs. It is beyond unacceptable that we pay, in some cases, 10 times more for the same exact prescription drugs than people in other major countries,” he said.

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