Dolphins (0-5) at Bills (4-1)

1 p.m. Sunday | Bills by 17 | O/U 411/2

All three levels of the Bills defense are playing

well, so this is a tall order for the winless Dolphins — even when Ryan Fitzpatrick can occasionally put up forehead-slapping numbers.

Bills 28, Dolphins 17

Jaguars (2-4) at Bengals (0-6)

1 p.m. Sunday | Jaguars by 41/2 | O/U 44

The winless Bengals are the worst team at

stopping the run, so that’s good news for

Leonard Fournette. They also don’t do a very good job of protecting Andy Dalton.

Jaguars 20, Bengals 16

Raiders (3-2) at Packers (5-1)

1 p.m. Sunday | Packers by 41/2 | O/U 461/2

The Raiders are on the road again after a stirring

win over the Bears in London. How well can the Packers stop Josh Jacobs? The bigger test: Aaron Rodgers for the Raiders’ pass defense.

Packers 27, Raiders 21

Texans (4-2) at Colts (3-2)

1 p.m. Sunday | Colts by 1 | O/U 47

Two very similar teams. Both can run, and

neither can stop the run. The Texans are coming off a big road win over the Chiefs, and the Colts are rested after a victory in K.C.

Texans 28, Colts 24

Rams (3-3) at Falcons (1-5)

1 p.m. Sunday | Rams by 3 | O/U 54

The Rams have lost three in a row. In their favor: they’re facing a defense that has given up a league-worst 31 points a game.

Rams 28, Falcons 23

Vikings (4-2) at Lions (2-2-1)

1 p.m. Sunday | Vikings by 21/2 | O/U 431/2

Expect a heavy dose of Dalvin Cook against

the Lions’ 28th-ranked run defense. With

the run established, Kirk Cousins can shine.

Vikings 31, Lions 23

Cardinals (2-3-1) at Giants (2-4)

1 p.m. Sunday | Giants by 3 | O/U 501/2

In a battle of rookie QBs, it’s Kyler Murray

vs. Daniel Jones. Both will face suspect pass defenses and could put up gaudy numbers.

The Giants are banged up on offense.

Cardinals 28, Giants 27

49ers (5-0) at Redskins (1-5)

1 p.m. Sunday | 49ers by 10 | O/U 40

The 49ers have a great running game, and they

get big yardage totals from tight end George Kittle. The Redskins can’t stop the run or the pass, and they’re vulnerable to tight ends.

49ers 28, Redskins 14

Chargers (2-4) at Titans (2-4)

4:05 p.m. Sunday | Titans by 21/2 | O/U 411/2

The Chargers can’t protect the football, nor

can they run — at least not so far. They’re also struggling to get to opposing QBs. That figures to change, and why not this week?

Chargers 24, Titans 21

Saints (5-1) at Bears (3-2)

4:25 p.m. Sunday | Bears by 4 | O/U 37

The Saints of the past had problems getting to

the QB; these ones don’t. That’s bad news for the Bears, who simply are trying to locate their QB. Another win for Teddy Bridgewater.

Saints 21, Bears 17

Ravens (4-2) at Seahawks (5-1)

4:25 p.m. Sunday | Seahawks by 3 | O/U 481/2

Lamar Jackson has been impressive running.

The Seahawks are equipped to stop him with those linebackers, though. Plus, Russell Wilson is on a tear.

Seahawks 27, Ravens 23

Eagles (3-3) at Cowboys (3-3)

8:20 p.m. Sunday | Cowboys by 21/2 | O/U 49

The Cowboys haven’t proved they can beat a

solid team. This might be the week to get back on track against a short-handed Eagles defense.

Cowboys 28, Eagles 27

Patriots (6-0) at Jets (1-4)

8:15 p.m. Monday | Patriots by 10 | O/U 44

The Jets are energized by the return of Sam Darnold. That doesn’t mean they’re going to stun the Patriots and their shutdown defense.

Patriots 24, Jets 14