Mary Tyler Moore, the multiple Emmy-winning actress who first charmed TV viewers on “The Dick Van Dyke Show” in the 1960s and became a beloved TV icon who could “turn the world on with her smile” on “The Mary Tyler Moore Show” in the 1970s, died Wednesday. She was 80.

In a career that began as Happy Hotpoint, the dancing and singing 3-inch pixie in Hotpoint appliance commercials on “The Adventures of Ozzie and Harriet” show in 1955 when she was 18, Moore went on to star in television and films and on Broadway.

In 1981, she received an Academy Award nomination for best actress for her portrayal of the emotionally cold mother in “Ordinary People,” the Robert Redford-directed drama about an upper-middle-class family dealing with the death of its eldest son in a boating accident with his brother.

The unsympathetic, dark role was a departure for Moore, who remains best known for her light touch in two classic situation comedies that, together, earned her six Emmy Awards.

Moore was still largely unknown when she was cast as Laura Petrie, the suburban housewife and mother of a young son opposite Van Dyke's TV comedy writer husband Rob on “The Dick Van Dyke Show.” The acclaimed sitcom, which aired on CBS from 1961 to 1966, earned Moore her first two Emmys and made her a star.

Her Capri-pants-wearing Laura brought something new to the traditional sitcom role of wife and mother: youthful sex appeal. As Carl Reiner, the series' creator, said of Rob and Laura in a 2004 TV Guide interview: “These were two people who really liked each other.”

Moore agreed, saying, “We brought romance to comedy, and, yes, Rob and Laura had sex!”

After the “Van Dyke” show ended in 1966, Moore starred as Holly Golightly later that year in a problem-plagued Broadway musical version of “Breakfast at Tiffany's” that producer David Merrick closed after four previews in New York.

Moore also played Julie Andrews' roommate in the hit 1967 flapper-era comedy-musical movie “Thoroughly Modern Millie.” But her budding film career, which included playing a nun opposite Elvis Presley's ghetto doctor in “Change of Habit,” was less than stellar.

Then she was reunited with Van Dyke in a 1969 musical-variety TV special, a critical and ratings success that spurred CBS to offer her a commitment to do her own half-hour comedy series.

Moore and her second husband, TV executive Grant Tinker, created MTM Enterprises, their own independent TV production company whose logo, in a takeoff on MGM's roaring lion, was a meowing orange kitten.

Tinker hired writers James L. Brooks and Allan Burns to create and produce “The Mary Tyler Moore Show,” which debuted on CBS in 1970 and made TV history. The series, featuring Moore as Mary Richards, a single woman in her 30s who lands a job as an associate producer in a Minneapolis TV newsroom, won 29 Emmys during its seven-year run.

Four of those Emmys went to Moore, whose character became a symbol of the independent 1970s career woman.

As Ed Asner's lovably gruff Lou Grant tells her when she applies for a job in the newsroom at WJM-TV: “You know what? You've got spunk. I hate spunk.”

The MTM empire grew to include such series as “The Bob Newhart Show,” “Rhoda,” “Lou Grant,” “Remington Steele,” “WKRP in Cincinnati,” “Hill Street Blues” and “St. Elsewhere.”

Moore received a special Tony Award in 1980 for her Broadway performance as the quadriplegic lead character in the Broadway revival of “Whose Life Is It Anyway?” a part originally written for a man.

In 1993, Moore won her seventh Emmy, for her supporting role as the ruthless owner of a 1940s Tennessee adoption agency in the Lifetime cable drama “Stolen Babies.”

But her two returns to the sitcom format in the mid- and late '80s, “Mary” and “Annie McGuire,” were short-lived, as was the 1995 newspaper drama “New York News,” on which she played the autocratic editor-in-chief of a tabloid newspaper.

In the years after “The Mary Tyler Moore Show,” she dealt with a series of personal problems and tragedies. In 1978, her younger sister, Elizabeth, died of a drug overdose. In 1980, Richie, her 24-year-old son from her first marriage, fatally shot himself in what was ruled an accident. And in 1992, Moore's brother John, a recovering alcoholic, died after a long battle with kidney cancer.

In the mid-'80s, Moore checked into the Betty Ford Center to seek treatment for alcoholism.

In a 1986 interview with Maclean's magazine, Moore said: “I am glad I was able to be a kind of role model for other women who identified with my ladylike qualities, who were then able to say, ‘Well, if Mary can admit she had a problem with alcohol, then maybe I can too.'?”

Moore was born in Brooklyn on Dec. 29, 1936. Her father was a clerk for Consolidated Edison, who later worked at the Southern California Gas Co. after the family moved to Los Angeles in 1945.

In her autobiography, Moore described her strict Catholic father as “undemonstrative” and her more fun-loving mother as an alcoholic. As a result, Moore spent half the time living with her parents and the other half living with her aunt and grandmother.

She was 18 and five months from graduating from high school in 1955 when she met 27-year-old Dick Meeker, an Ocean Spray cranberry products salesman, who moved into a small apartment in the house next door to her parents' home. They were married two months after she graduated, and their son, Richie, was born the following year.

Moore, whose first marriage ended in divorce in 1961, married Tinker in 1962. They were divorced in 1981. In 1983, Moore married Dr. Robert Levine, a Manhattan cardiologist, who survives her.

Moore, who was diagnosed with Type 1 diabetes in 1969, later served as the international chairman of the Juvenile Diabetes Foundation.

In 2012, she received the Screen Actors Guild Life Achievement Award.