DETROIT — Clay Buchholz pitched well enough to give the road-weary Boston Red Sox a chance to win.

The bullpen couldn't finish the job.

Brad Ziegler walked Andrew Romine with the bases loaded to cap a three-run eighth inning for Detroit, and the Tigers held on for a 4-3 win Thursday, ending Boston's six-game winning streak.

The Red Sox won in Baltimore on Wednesday night, and manager John Farrell said they arrived at their hotel around 4?a.m. Thursday. David Ortiz and Dustin Pedroia were out of the starting lineup.

“I thought we brought great energy considering the circumstances coming into this ballgame,” Farrell said. “We fought hard.”

Boston played in its fourth city in five days. The team was home at Fenway Park on Sunday, had a makeup game Monday in Cleveland, then a two-game series at Camden Yards.

Buchholz and Detroit's Matt Boyd each allowed a run in six innings.

“I felt good. I went out of the stretch the whole start, less moving parts for me, just things I've been working on,” Buchholz said. “I feel like that keeps me over the rubber a little bit longer and enables me to command a little bit better.”

The Red Sox scored twice in the eighth to go up 3-1, but the Tigers rallied. Miguel Cabrera's run-scoring single made it 3-2 and gave him 1,000 RBIs for his Detroit tenure — and 1,523 overall in a career that started in 2003 with the Florida Marlins.

“Playing eight, nine years here, it made me proud, because you don't see that too often right now because all the trades, the situation around baseball,” Cabrera said. “It's hard to play with one team for a long time.”

Ziegler came on and allowed a tying single to Victor Martinez. J.D. Martinez walked to load the bases with nobody out, but a grounder and a strikeout left the bases still loaded.

Romine then drew a walk to put Detroit ahead.

Boston threatened in the ninth against Francisco Rodriguez. Ortiz's pinch-hit single put men on first and second with one out, and Xander Bogaerts moved the runners over with a groundout. Mookie Betts hit a line drive, but second baseman Ian Kinsler, well positioned, needed to move only slightly to his right to make the catch for the final out.

Rodriguez got his 34th save in 37 chances.