Eli Manning threw a 3-yard touchdown pass to Sterling Shepard with 53 seconds left and the New York Giants snapped a five-game losing streak by beating the San Francisco 49ers, 27-23, on Monday night.

Manning threw two TD passes to Odell Beckham Jr. and then engineered the late game-winning drive with help from a pair of third-down penalties against Malcolm Smith and Ahkello Witherspoon.

Saquon Barkley then had a 23-yard catch to get the ball into the red zone and Manning connected with Shepard on third down to give the Giants (2-7) the win.

Matt Breida ran for 101 yards and scored two touchdowns for the 49ers (2-8), who were unable to win consecutive games under third-string quarterback Nick Mullens. Breida's 23-yard run helped set up a 30-yard field goal by Robbie Gould that gave the Niners a 23-20 lead with 2:46 to play.

Bengals changes: Marvin Lewis got the Bengals’ head coaching job because of his reputation for defensive excellence. He’s now in charge of trying to resuscitate a historically bad unit and pulling the team’s season back from the brink.

The Bengals fired defensive coordinator Teryl Austin on Monday, a day after a 51-14 loss to the Saints that ranks among the worst in franchise history. The Saints scored on every possession except the last one — when it took a knee while in field-goal range — during its rout at Paul Brown Stadium.

Lewis will bring in former Browns head coach Hue Jackson to serve in some capacity on the staff, according to multiple reports.

Jackson, 53, never has coached defense, but he spent two stints as a Bengals offensive and special teams assistant under Lewis.

The fading Bengals (5-4) fired a coordinator in midstream for the second season in a row.

Bowles still Jets coach: Todd Bowles is staying put as coach of the Jets. For now, at least.

It was business as usual Monday for Bowles, whose job status appeared extremely shaky after the Jets’ embarrassing 41-10 loss to the Bills on Sunday, their fourth consecutive defeat that dropped the team to 3-7.

“We picked a bad day to have a bad day,” Bowles said during a conference call.

Owner Christopher Johnson opted to not fire Bowles, who’s 23-35 with a .397 winning percentage.

Rams lose WR Kupp: Receiver Cooper Kupp will miss the rest of the season after tearing a ligament in his left knee during Sunday’s 36-31 win over the Seahawks. Coach Sean McVay confirmed the ACL injury for Kupp, who led the Rams in yards receiving last season. Kupp likely will undergo surgery this week. Kupp has 40 catches for 566 yards and six touchdowns this season, providing reliable hands in the slot and a knack for big catches.

Extra points: Chargers LB Denzel Perryman will miss the rest of the season after injuring the LCL in his left knee during Sunday’s win over the Raiders. ... Jaguars C Brandon Linder will undergo season-ending surgery after injuring his right knee during Sunday’s loss to the Colts. ... The Bills released QB Nathan Peterman, who began the season as the team’s starter. He threw seven INTs in 81 pass attempts.