Q: I often hear about the medicinal benefits of various herbs and spices. However, I don’t typically hear about pepper, a widely available spice. Has there been any research to suggest what benefits it may have?

A: Black pepper (Piper nigrum) has been prized for millennia. The pharaohs of ancient Egypt were mummified with peppercorns in their nostrils, presumably to signify their high status in the afterlife. Venetian merchants were able to build luxurious mansions in large part because they controlled the trade in spices, especially black pepper, during the 15th century.

Although pepper is no longer considered a luxury spice, it does appear to have medicinal benefits. Researchers are exploring the power of piperine, a key component of black pepper, as an anticancer agent (Current Medicinal Chemistry, online, May 23, 2017).

Piperine is an antioxidant and antimicrobial compound. In addition, it lowers blood cholesterol, fights inflammation, improves digestion and increases absorption of some herbal and conventional drugs (Phytotherapy Research, August 2013). One of these is turmeric (curcumin), which is notoriously hard to absorb.

Q: I have a thyroid condition called Hashimoto’s. My TSH is usually normal, but my thyroid antibodies are almost always abnormal in thyroid panel tests.

A year ago, my doctor finally prescribed Synthroid. I consistently had normal tests, but my symptoms got worse. I could not lose weight, and my hair was falling out. I was depressed and tired, but I had problems sleeping. I felt like my brain was in a fog.

Last week my doctor switched me to Armour desiccated thyroid. I am already feeling sharper and more upbeat. Why isn’t Armour used more often?

A: In Hashimoto’s thyroiditis, the immune system attacks the thyroid gland. That is why your anti-thyroid antibodies have been elevated. The consequence of this condition is that the thyroid gland may lose its ability to produce adequate thyroid hormone.

An underactive thyroid gland is usually treated with synthetic levothyroxine (Synthroid, Levothroid, Levoxyl). This is also called T4. The tissues of the body convert T4 to T3, the active thyroid hormone, when they need it.

Armour and other desiccated thyroid extracts are derived from dried pig thyroid glands. It contains T3 as well as T4, although the ratio differs from that of human thyroids. Some people do not convert T4 to T3 efficiently. They may feel better on a medication that supplies both hormones. Many endocrinologists worry, however, that controlling the dose with naturally variable preparations is too difficult.

Q: I noticed a plantar wart on the ball of my foot two months ago. Salicylic acid plasters did not work. What home remedies could I try?

A: Readers suggest mixing turmeric with olive oil and applying a small amount to the wart under a waterproof bandage. Others have had success with a daily drop of tincture of iodine, tea tree oil, clear nail polish or peppermint oil.

Q: I have taken zolpidem (Ambien) for years. You have written about the dangers of such sleep aids, so I decided to cut back. I spent several weeks hardly sleeping at all.

Melatonin has been helpful, though not perfect. Does it have side effects?

A. Melatonin is a hormone that the brain makes as it is getting ready to gear down for the night. That is why this compound has a reputation as helpful for sleep.

Melatonin has been used to help people like you reduce their reliance on benzodiazepine or Z-type sleeping pills such as zolpidem (European Journal of Pharmacology, Sept. 5, 2015). A randomized trial showed that melatonin could improve sleep quality in people who have suffered traumatic brain injury (BMC Medicine, Jan. 19, 2018). It also has been used to help cancer patients sleep (Aging Clinical and Experimental Research, October 2013). Melatonin does not appear to trigger serious side effects, although some people report nausea, dizziness or headaches.

In their column, Joe and Teresa Graedon answer letters from readers. Send questions to them via www.peoplespharmacy.com.